Drug Uses

Zithromax is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, skin infections, ear infections, and sexually transmitted diseases.

How Taken

Zithromax comes as a capsule, tablet, and liquid to take it orally. It is usually taken once a day for 2-5 days. Take Zithromax exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. The capsules and tablets should be taken with a full glass of water. Continue to take Zithromax even if you feel well. Do not stop taking Zithromax without talking to your doctor. Take Zithromax liquid at least 1 hour before or 2 hours after meals. The capsule and tablet may be taken with or without food. If it upsets your stomach, take it with food.

Warnings/Precautions

Before taking Zithromax, tell your doctor if you have liver disease. You may not be able to take Zithromax, or you may require a lower dose or special monitoring during treatment. Zithromax is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Zithromax passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Zithromax and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue). Other, less serious side effects may be more likely to occur. Continue to take Zithromax and talk to your doctor if you experience nausea, vomiting, diarrhea, or abdominal pain; unusual dizziness, fatigue, or headache; vaginal yeast infection; a rash; or increased sensitivity to sunlight. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Zithromax tablets should be stored between 15° to 30° C (59° to 86°F). Store constituted suspension between 5° to 30°C (41° to 86°F) and discard when full dosing is completed or within 10 days. Shake well before each use. Oversized bottle provides shake space. Keep tightly closed.

Overdose

Seek emergency medical attention. Symptoms of Zithromax overdose include nausea, vomiting, diarrhea, and abdominal discomfort.

More Information

Avoid prolonged exposure to sunlight. Zithromax may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Agriculture (USDA), evaluated whether food crops accumulate antibiotics from soils spread with manure that contains antibiotics. Results from the study are published in the July-August 2007 issue of the Journal of Environmental Quality. The research was also presented in Indianapolis, IN at the Annual Soil Science Society of America Meeting in November 2006.
Plant uptake was evaluated in a greenhouse study involving three food crops: corn, lettuce, and potato. Plants were grown on soil modified with liquid hog manure containing Sulfamethazine, a commonly used veterinary antibiotic. This antibiotic was taken up by all three crops. Concentrations of antibiotics were found in the plant leaves. Concentrations in plant tissue also increased as the amount of antibiotics present in the manure increased. It also diffused into potato tubers, which suggests that root crops, such as potatoes, carrots, and radishes, that directly come in contact with soil may be particularly vulnerable to antibiotic contamination.
The ability of plants to absorb antibiotics raises the potential for contamination of human food supply. However, Satish Gupta, group leader notes "The adverse impacts of consuming plants that contain small quantities of antibiotics are largely unknown". Consumption of antibiotics in plants may cause allergic reactions in sensitive populations, such as young children. There is also concern that consuming antibiotics may lead to the development of antimicrobial resistance, which can render antibiotics ineffective.
Holly Dolliver, the lead scientist in this study, notes that antibiotics consumed by plants may be of particular concern to the organic farming industry. Manure is often the main source of crop nutrients for organic food production, since regulations prohibit the use of synthetic fertilizers. According to the USDA, producers must manage animal materials in a manner that does not contribute to contamination of crops by residues of prohibited substances, which includes antibiotics. However, manures containing antibiotics are not formally banned or prohibited.
Further research is needed to investigate the presence of antibiotics in edible parts of plants, especially vegetables that are consumed raw, and how different plants absorb different antibiotic compounds. Research is ongoing at the University of Minnesota to further investigate the potential fate and transport of antibiotics introduced to the environment from livestock operations.

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