Drug Uses

Use Tetracycline to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

How Taken

The usual daily dose is 1g to 2g. Your doctor may increase the dosage in case of severe infections. You should continue therapy for at least 24 to 48 hours after the symptoms and fever have subsided.

Warnings/Precautions

Talk to your physician before taking this medicine if you are hypersensitive to tetracyclines. Using Tetracycline in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit and increases the risk of the development of drug-resistant bacteria.

Missed Dose

If you skip doses or do not complete the full course of therapy, you may risk a decrease in the effectiveness of the immediate treatment. Also there is a chance that bacteria will develop resistance and will not be treatable by Tetracycline or other antibacterial drugs in the future.

Possible Side Effects

Side effects you may experience may include: anorexia, epigastric distress, nausea, vomiting, diarrhea, bulky loose stools, stomatitis, sore throat, glossitis, black hairy tongue, dysphagia, hoarseness, enterocolitis, and inflammatory lesions (with candidal overgrowth) in the anogenital region.

Storage

Store the tablets at room temperature; avoid excessive heat. Dispense in tight, light-resistant containers. Keep out of the reach of children.

Overdose

In case of overdosage, seek emergency medical attention.

More Information

If you are undergoing long-term therapy, periodic laboratory evaluation of organ system function, including renal, hepatic, and hematopoietic systems, should be performed.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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MARKHAM, ON, March 6 /CNW/ - Wyeth Pharmaceuticals today announced that
Tygacil(TM)(tigecycline), a new intravenous (I.V.) antibiotic with a broad
spectrum of antimicrobial activity against drug-resistant bacteria, including
methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant
enterococci (VRE), is now available for sale to Canadian hospitals following
its recent approval by Health Canada. Tygacil, the first glycylcycline, is a
new antibiotic indicated for the treatment of complicated intra-abdominal
infections (cIAI) and complicated skin and skin structure infections (cSSSI)
in adults(1).
"The increase in multiple drug-resistant pathogens in our hospitals and
communities needs to be at the forefront of concern in Canada," says
Dr. George Zhanel, Professor, Department of Medical Microbiology, Faculty of
Medicine, at the University of Manitoba, and lead investigator in the CAN-ICU
study which examined the prevalence of these antibiotic-resistant bacteria in
Canadian intensive care units. "The availability of Tygacil comes at a time
when new and effective antibiotics are needed to assist us in combating rising
rates of resistant bugs in hospitals. Tygacil will be an important weapon in
our fight."
The interim CAN-ICU study data, released in September, 2006 in Winnipeg,
indicated that the incidence of resistant bacteria was much higher than
previously believed. It revealed that among S. aureus bacteria, which is a
major cause of hospital-acquired wound and skin infections, on average one in
five (20 per cent) and as high as one-half (50 per cent) were resistant to the
antibiotic methicillin(2). This is higher than previous estimates, which
suggested MRSA had a prevalence of between 5 and 15 per cent(3). Researchers
also found a 6.7 per cent prevalence of VRE(4) and a 4.7 per cent prevalence
of antibiotic-resistant E. coli(5).
Tygacil Exhibits Activity Against Potent Bacteria
Effective against a wide variety of bacteria, Tygacil can be used
empirically (before specific bacteria have been identified) at the onset of
treatment. Tygacil can be used alone to treat a variety of cIAI and cSSSI
infections, including complicated appendicitis, infected burns,
intra-abdominal abscesses, deep soft tissue infections, and infected ulcers.
In addition, Tygacil does not require dosage adjustment in patients with
impaired renal function, and is conveniently dosed every 12 hours(6).
The economic impact of patients who suffer from infections due to
resistant pathogens is far reaching. It is estimated that the annual cost of
MRSA and managing infected patients is $42 million to $59 million for all
Canadian hospitals(7).
The increasing prevalence of resistant bacteria often necessitates the
use of combinations of antibiotics to fight infections. About 70 per cent of
hospital-acquired infections are resistant to at least one drug(9). According
to the U.S. Centers for Disease Control and Prevention, antibiotic resistance
has become so widespread that many significant bacterial infections in the
world are becoming resistant to commonly used antibiotics(10). New classes of
antibiotics are needed to address increasing antibiotic resistance among
common pathogens(11).
About Tygacil
Tygacil, the first glycylcycline, was developed by Wyeth to overcome two
key mechanisms of resistance that have limited the use of a number of
antibiotics. It is now commercially available for sale in Canada to hospital
pharmacists, who can order the product directly from Wyeth.
In clinical trials, treatment with Tygacil alone provided comparable
clinical cures rates in cSSSI to vancomycin in combination with aztreonam.
Treatment with Tygacil also provided clinical cure rates comparable to
imipenem/cilastatin, a treatment for cIAI. The overall discontinuation rate
for Tygacil (4.9 per cent) was comparable to vancomycin and aztreonam (5.3 per
cent) and imipenem/cilastatin (4.4 per cent).

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