Drug Uses

Motrin Tablets are used for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Take this medicine for the relief of mild to moderate pain. Your doctor may prescribe Motrin for the treatment of primary dysmenorrhea.

How Taken

Do not exceed 3200 mg total daily dose. If you experience gastrointestinal toxicity, take Motrin Tablets with meals or milk.

Warnings/Precautions

You should not take Motrin if you have previously exhibited hypersensitivity to the drug, or have the syndrome of nasal polyps, angioedema and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory agents. Serious gastrointestinal toxicity such as bleeding, ulceration, and perforation, can occur at any time, with or without warning symptoms.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Possible Side Effects

The most frequent type of adverse reaction you may experience with Motrin Tablets is gastrointestinal. Blurred and/or diminished vision, scotomata, and/or changes in color vision have also been reported.

Storage

Store at controlled room temperature 20° to 25°C (68° to 77°F).

Overdose

In case of overdosage, the stomach should be emptied by vomiting. Seek emergency medical attention.

More Information

While on Motrin therapy, you should report to your physician any signs or symptoms of gastrointestinal ulceration or bleeding, blurred vision or other eye symptoms, skin rash, weight gain, or edema.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The nutritional supplement glucosamine boosts the pain relieving power of ibuprofen, according to a new study by Temple University researchers in the Journal of Pharmacology and Experimental Therapeutics (JPET). This new drug combination could one day allow patients to take a lower dose and get the same pain relief with fewer unwanted side effects.
Ronald Tallarida, Ph.D., and Alan Cowan, Ph.D., of Temple's School of Medicine, and Robert Raffa, Ph.D., of Temple's School of Pharmacy, conducted the study "Antinociceptive Synergy, Additivity, and Subadditivity with Combinations of Oral Glucosamine Plus Nonopioid Analgesics in Mice," which was published in the November 2003 issue of JPET.
Ibuprofen is a non-steroidal anti-inflammatory drug, or NSAID. NSAIDs, which also include aspirin, are quite effective in relieving pain. They are so effective, in fact, that pain sufferers sometimes take higher and higher doses in hope of more pain relief. High doses of NSAIDs, especially when taken over long periods of time, can cause gastrointestinal upset, such as heartburn, or even bleeding.
"Combining pain relievers into one pill can increase patient compliance, simplify prescribing, and improve efficacy without increasing side effects, or conversely, decrease side effects without losing efficacy," said Raffa.
In addition to these benefits, drug combinations can also sometimes yield a totally unexpected effect, such as the magnification of a drug's powers. "When this happens, a phenomenon known as drug synergism, it's like finding buried treasure," added Tallarida.
Glucosamine, a naturally occurring substance in the body, which is also available in synthetic form over the counter, is used to treat osteoarthritis, a painful, degenerative joint disorder. While it has been shown to prevent and repair bone and cartilage damage, researchers have yet to demonstrate that glucosamine actually blocks pain.
"We embarked on this study with several questions: Can glucosamine actually block pain? And, can glucosamine improve the pain-relieving powers of other drugs when the two are combined?" said Tallarida.
First, the researchers confirmed that glucosamine, alone, does not block pain. It's believed that any pain-relieving properties of glucosamine are a side effect of its ability to repair bone damage. Next, they combined glucosamine with a variety of NSAIDs at a variety of dosages. With several NSAIDs, including naproxen, the addition of glucosamine caused an additive effect, meaning the sum of each drug's properties. When combined with aspirin or acetaminophen, the result was subadditive, or less than the sum of each drug's properties. But when combined with ibuprofen, the researchers found pain relief was enhanced and therefore synergistic.
"The next step will be to study this drug combination in clinical trials to see whether it can enhance pain relief or offer pain relief using a lower dose of ibuprofen and therefore a lower risk of side effects," said Cowan.
The researchers are also investigating other possible drug combinations for the potential relief of pain. Raffa and Tallarida played a role in the development of Ultracet, a combination of tramadol and acetominophen used in the treatment of pain. And Cowan contributed to the development of buprenorphine which, when combined with naloxone, is used in the treatment of opiate addiction.

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