Drug Uses

Fluoxetine is a drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder, and many other disorders. It is a psychotropic drug for oral administration.

How Taken

Fluoxetine usually is taken once or twice a day. To be effective, it should be taken regularly. Make a habit of taking it at the same time you do some other daily activity. It may be 4 weeks before you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen. For obsessive-compulsive disorder, the full effect may take 5 weeks to appear.

Warnings/Precautions

Unless you are directed to do so by your doctor, do not take this medication if you are recovering from a heart attack or if you have liver disease or diabetes. Fluoxetine may cause you to become drowsy or less alert and may affect your judgment. Therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended. While taking this medication, you may feel dizzy or light-headed or actually faint when getting up from a lying or sitting position. If getting up slowly doesn't help or if this problem continues, notify your doctor. If you develop a skin rash or hives while taking Fluoxetine, discontinue use of the medication and notify your doctor immediately. Fluoxetine should be used with caution if you have a history of seizures. You should discuss all of your medical conditions with your doctor before taking this medication. Fluoxetine can occasionally cause decreased appetite and weight loss, especially in depressed people who are already underweight and in those with bulimia. If you notice changes in your weight or appetite, tell your doctor. The effects of Fluoxetine during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. This medication appears in breast milk, and breastfeeding is not recommended while you are taking Fluoxetine.

Missed Dose

If you miss a dose of Fluoxetine and you remember the same day, take it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Possible Side Effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Fluoxetine.
More common side effects may include:
Abnormal dreams, abnormal ejaculation, abnormal vision, anxiety, diminished sex drive, dizziness, dry mouth, flu-like symptoms, flushing, gas, headache, impotence, insomnia, itching, loss of appetite, nausea, nervousness, rash, sinusitis, sleepiness, sore throat, sweating, tremors, upset stomach, vomiting, weakness, yawning.
Less common side effects may include:
Abnormal taste, agitation, bleeding problems, chills, confusion, ear pain, emotional instability, fever, frequent urination, high blood pressure, increased appetite, loss of memory, palpitations, ringing in the ears, sleep disorders, weight gain.
In children and adolescents, less common side effects may also include: Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or hypomania (inappropriate feelings of elation and/or rapid thoughts), nosebleeds, personality changes, and thirst.
A wide variety of other very rare reactions have been reported during Fluoxetine therapy. If you develop any new or unexplained symptoms, tell your doctor without delay.

Storage

Store in a dry place at 20-25 degrees C (68-77 F).

Overdose

Any medication taken in excess can have serious consequences. An overdose of Fluoxetine can be fatal. In addition, combining Fluoxetine with certain other drugs can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately. Common symptoms of Fluoxetine overdose include : Nausea, rapid heartbeat, seizures, sleepiness, vomiting. Other symptoms of Fluoxetine overdose include: Coma, delirium, fainting, high fever, irregular heartbeat, low blood pressure, mania, rigid muscles, sweating, stupor.

More Information

Do not take with MAO inhibitors or for at least two weeks after their discontinuation. MAO inhibitor medications should not be taken for at least five weeks after discontinuing Fluoxetine. Most medications affecting the brain have the potential to slow reflexes or impair judgment and caution is advised. This medication has not been studied extensively in the US and re-evaluation periodically by your physician is advised. Check with you pharmacist when taking with other medications.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Most of the Americans pay more for essential prescription medicines than the neighboring countries like Canada. And adding to this is the aggressive pricing policies of American pharmacy companies. The prices remain to continue to rise in the US, while they remain much less expensive in other countries. This disparity in prices has led to a rise in the popularity of Fluoxetine.These discount pharmacies sell branded as well as exact generic equivalents of US FDA approved prescription drugs at a discounted rate, some even claiming to a saving of 70% off retail prices as they order in bulk.


Q: How does the online consultation for Fluoxetine work?
A: Online consultations utilizes the Internet to improve patient access to the physician. The patient no longer needs to receive a traditional physical exam by the physician. Now he simply completes an online questionnaire for Fluoxetine, and this questionnaire is then submitted to the physician using our secure order system. The online consultations can never take the place of traditional medicine, they do provide a valid means for patients to receive treatment for a number of conditions that, in many circumstances, do not actually require a physical exam.


Thousands of people in the UK could be hooked on the anti-depressant drug Seroxat, without knowing it.
Dr David Healy, a UK expert in antidepressants, has said he has seen records of trials carried out by the manufacturers which showed healthy volunteers were suffering withdrawal symptoms after taking the drug for just a couple of weeks.
He said more than half of people on Seroxat may have "significant" withdrawal problems.
He said: "For most people who take the drug, one of the key points that will concern people is that Seroxat (paroxetine) could make you physically dependent."
Dr Healy, director of the North Wales department of psychological medicine was given access to the results of early trials of the drugs while a witness in a US case.
The case dealt with a seperate concern about the drug, which is that some people who take it could become violent towards themselves or others.
The family of David Snell won a $6.4m payout from manufacturers GlaxoSmithKline (GSK) after Mr Snell was found to have murdered three members of his family, and himself, after taking the drug for just two days.
The company denies the link and is appealing against the decision.
Two weeks earlier, in Australia, a judge ruled Sertraline, a drug in the same family, had caused David Hawkins to murder his wife and attempt to kill himself.
Dr Healy told BBC News Online, of the 100m people world-wide who were on Seroxat, one in 1,000 could have a suicidal reaction.
There have been concerns expressed in the past about antidepressants such as Prozac making healthy people with no history of mental illness feel violent.
New generation
Seroxat is part of a family of antidepressants called SSRIs (selective serotonin re-uptake inhibitor) which were introduced to the market in the early 1990s.
They were a replacement for benzodiazepines such as Valium and Librium - and their selling point was that people would not become physically dependent on them, unlike the older drugs.
Dr Healy was given access to GSK's archives because he was an expert witness in the Snell case.
And he said a trial a study of 34 healthy company workers by GSK, carried out before Seroxat was licensed, showed 25% became agitated.
Dr Healy believes a small number could be so disturbed by the effects of SSRIs that they could kill.
He said some of those involved in the pre-licensing trial had gone on to "suicidal acts".
He wrote to the Medicines Control Agency, which grants drug licenses in the UK, and said: "The relationship between their intake of paroxetine (Paxil/Seroxat) and later suicidal acts is a matter about which neither you, nor SmithKline Beecham should be sanguine."
Dr Healy said the company has failed to pass on information to patients or doctors.
He says a study which looked at the effect of stopping the drug for people who had successfully been treated for the depression showed many got worse.
The company argued this meant the drug should be licensed for long term treatment of depression.
Dr Healy says this is potentially more evidence that the participants in the trial were suffering withdrawal symptoms
He said the drug should carry warnings that some people who take it may experience violent or unusual thoughts, which were linked to the drug and not their condition.
And he said doctors who were treating people who suffered symptoms after coming off the drug "should be aware that maybe the underlying problem has cleared up and maybe the symptoms are due to withdrawal."
A World Health Organization report which ranked antidepressants in order of withdrawal problems found Seroxat was the hardest to come off.
Prozac (fluoxetine) was seventh.
Alan Chandler, a spokesman for GSK denied Seroxat was causing dependency, withdrawal symptoms or violent tendencies.
He said independent analysis last year by the MCA and others had concluded SSRIs did not cause dependency.
He said: "Withdrawal symptoms may occur with all SSRIs if treatment is abruptly stopped. This is not a sign of addiction or depression."

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