Drug Uses

Amoxil is an antibiotic in the class of drugs called penicillin. It fights bacteria in the body. Amoxil is used to treat many different types of infections, such as tonsillitis, pneumonia, ear infections, bronchitis, urinary tract infections, gonorrhea, and infections of the skin. Amoxil may also be used for other purposes.

How Taken

Amoxil comes as a capsule, chewable tablet, liquid, and pediatric drop to take by mouth. It is usually taken every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amoxil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid and pediatric drops well before each use to mix the medication evenly. Use the bottle dropper to measure the dose of pediatric drops. The pediatric drops and liquid may be placed on a child's tongue or added to formula, milk, fruit juice, water, ginger ale, or other cold liquid and taken immediately. The tablets should be crushed or chewed thoroughly before they are swallowed. The capsules should be swallowed whole and taken with a full glass of water. Continue to take Amoxil even if you feel well. Do not stop taking Amoxil without talking to your doctor.

Warnings/Precautions

If you have ever had an allergic reaction to another penicillin or to a cephalosporin, do not take Amoxil without first talking to your doctor. Before taking Amoxil, tell your doctor if you have kidney disease, or stomach or intestinal disease. Amoxil is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Amoxil is generally considered to be safe for use during pregnancy. Do not, however, take Amoxil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Amoxil passes into breast milk. Although serious problems have not been reported, rarely, Amoxil may cause a yeast infection, diarrhea, or an allergic reaction in a nursing infant, although no serious harm is expected. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember, and take the rest of the day's doses at evenly spaced intervals. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and take the rest of the doses for the day as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. If you experience any of the following serious side effects, stop taking Amoxil and seek emergency medical attention or contact your doctor immediately: an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); seizures; or unusual bleeding or bruising. Other, less serious side effects may be more likely to occur. Continue to take Amoxil and talk to your doctor if you experience mild nausea, vomiting, diarrhea, or abdominal pain, white patches on the tongue (thrush/ yeast infection); itching or discharge of the vagina (vaginal yeast infection); black, "hairy" tongue or sore mouth or tongue. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Keep out of the reach of children. Store away from heat and direct light. Do not store the capsule or tablet form of Amoxil in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. Store the oral liquid form of Amoxil in the refrigerator because heat will cause this medicine to break down. However, keep the medicine from freezing. Follow the directions on the label. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Overdose

Symptoms of an Amoxil overdose may include muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, or agitation. Seek emergency medical attention if an overdose is suspected.

More Information

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. Take all of the Amoxil that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Amoxil may decrease the effectiveness of birth control pills. If you are taking birth control pills, use a second method of birth control while taking Amoxil to ensure protection from unintended pregnancy.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Q: Do you deliver Amoxicillin to my state?
A: Due to regulations we cannot ship medicines to all states, please check the order form for the current list of states that we can ship to.


MARKHAM, ON, March 6 /CNW/ - Wyeth Pharmaceuticals today announced that
Tygacil(TM)(tigecycline), a new intravenous (I.V.) antibiotic with a broad
spectrum of antimicrobial activity against drug-resistant bacteria, including
methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant
enterococci (VRE), is now available for sale to Canadian hospitals following
its recent approval by Health Canada. Tygacil, the first glycylcycline, is a
new antibiotic indicated for the treatment of complicated intra-abdominal
infections (cIAI) and complicated skin and skin structure infections (cSSSI)
in adults(1).
"The increase in multiple drug-resistant pathogens in our hospitals and
communities needs to be at the forefront of concern in Canada," says
Dr. George Zhanel, Professor, Department of Medical Microbiology, Faculty of
Medicine, at the University of Manitoba, and lead investigator in the CAN-ICU
study which examined the prevalence of these antibiotic-resistant bacteria in
Canadian intensive care units. "The availability of Tygacil comes at a time
when new and effective antibiotics are needed to assist us in combating rising
rates of resistant bugs in hospitals. Tygacil will be an important weapon in
our fight."
The interim CAN-ICU study data, released in September, 2006 in Winnipeg,
indicated that the incidence of resistant bacteria was much higher than
previously believed. It revealed that among S. aureus bacteria, which is a
major cause of hospital-acquired wound and skin infections, on average one in
five (20 per cent) and as high as one-half (50 per cent) were resistant to the
antibiotic methicillin(2). This is higher than previous estimates, which
suggested MRSA had a prevalence of between 5 and 15 per cent(3). Researchers
also found a 6.7 per cent prevalence of VRE(4) and a 4.7 per cent prevalence
of antibiotic-resistant E. coli(5).
Tygacil Exhibits Activity Against Potent Bacteria
Effective against a wide variety of bacteria, Tygacil can be used
empirically (before specific bacteria have been identified) at the onset of
treatment. Tygacil can be used alone to treat a variety of cIAI and cSSSI
infections, including complicated appendicitis, infected burns,
intra-abdominal abscesses, deep soft tissue infections, and infected ulcers.
In addition, Tygacil does not require dosage adjustment in patients with
impaired renal function, and is conveniently dosed every 12 hours(6).
The economic impact of patients who suffer from infections due to
resistant pathogens is far reaching. It is estimated that the annual cost of
MRSA and managing infected patients is $42 million to $59 million for all
Canadian hospitals(7).
The increasing prevalence of resistant bacteria often necessitates the
use of combinations of antibiotics to fight infections. About 70 per cent of
hospital-acquired infections are resistant to at least one drug(9). According
to the U.S. Centers for Disease Control and Prevention, antibiotic resistance
has become so widespread that many significant bacterial infections in the
world are becoming resistant to commonly used antibiotics(10). New classes of
antibiotics are needed to address increasing antibiotic resistance among
common pathogens(11).
About Tygacil
Tygacil, the first glycylcycline, was developed by Wyeth to overcome two
key mechanisms of resistance that have limited the use of a number of
antibiotics. It is now commercially available for sale in Canada to hospital
pharmacists, who can order the product directly from Wyeth.
In clinical trials, treatment with Tygacil alone provided comparable
clinical cures rates in cSSSI to vancomycin in combination with aztreonam.
Treatment with Tygacil also provided clinical cure rates comparable to
imipenem/cilastatin, a treatment for cIAI. The overall discontinuation rate
for Tygacil (4.9 per cent) was comparable to vancomycin and aztreonam (5.3 per
cent) and imipenem/cilastatin (4.4 per cent).

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